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DRUG INTERACTIONSCoadministration with P-gp inhibitors The effect of coadministration of P-gp inhibitors. No dose adjustment is required for patients with deleterious or suspected deleterious germline breast cancer susceptibility gene (BRCA)-mutated (gBRCAm) human epidermal growth factor receptor 2 (HER2)-negative locally advanced or metastatic breast cancer.